Palladium catalysed tetramolecular queuing cascades of aryl iodides, carbon monoxide, amines and a polymer supported allene

被引:30
作者
Grigg, R [1 ]
MacLachlan, W
Rasparini, M
机构
[1] Univ Leeds, Sch Chem, MIDAS Ctr, Leeds LS2 9JT, W Yorkshire, England
[2] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England
关键词
D O I
10.1039/b007170f
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Chemo- and regio-specific palladium catalysed four component processes, involving formation of 3 new bonds, initiated by oxidative addition of Pd(0) with aryl iodides followed by sequential incorporation of CO (1 atm), a polymer supported allene and an amine provides complex heterocycles with 3 points of diversity in good yield and excellent purity after cleavage.
引用
收藏
页码:2241 / 2242
页数:2
相关论文
共 5 条
  • [1] Palladium catalysed tetramolecular cascade processes incorporating allene and carbon monoxide
    Grigg, R
    Brown, S
    Sridharan, V
    Uttley, MD
    [J]. TETRAHEDRON LETTERS, 1997, 38 (28) : 5031 - 5034
  • [2] Palladium catalysed cascade cyclisation-anion capture, relay switches and molecular queues
    Grigg, R
    Sridharan, V
    [J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1999, 576 (1-2) : 65 - 87
  • [3] GRIGG R, UNPUB
  • [4] Novel polymer-supported trialkylsilanes and their use in solid-phase organic synthesis
    Hu, YH
    Porco, JA
    Labadie, JW
    Gooding, OW
    Trost, BM
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (13) : 4518 - 4521
  • [5] OBSERVATION ON THE SYNTHESIS OF ALLENES BY HOMOLOGATION OF ALK-1-YNES
    SEARLES, S
    LI, Y
    NASSIM, B
    LOPES, MTR
    TRAN, PT
    CRABBE, P
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1984, (04): : 747 - 751