Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents

被引：90

作者：

Calí, P

Nærum, L

Mukhija, S

Hjelmencrantz, A

机构：

[1] Combio AS, DK-1800 Frederiksberg C, Denmark

[2] Arpida Ltd, CH-4142 Munchenstein, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 24期

关键词：

peptide deformylase; inhibitors; antibacterial;

D O I：

10.1016/j.bmcl.2004.09.087

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of isoxazole-3-hydroxamic acid derivatives has been identified as a new class of small, nonpeptidic inhibitors of peptide deformylase (PDF). The synthesis, enzyme inhibition and preliminary investigation of the binding mode of this potential antibacterial compounds are reported. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：5997 / 6000

页数：4

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