Asymmetric routes towards polyfunctionalized pyrrolidines: Synthesis and reactivity of a chiral silyloxypyrrole.

被引：39

作者：

Baussanne, I ^{[1
]}

Royer, J ^{[1
]}

机构：

[1] INST CHIM SUBST NAT,CNRS,F-91198 GIF SUR YVETTE,FRANCE

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 08期

关键词：

D O I：

10.1016/0040-4039(95)02388-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from O-protected (R)-(-)-phenylglycinol, chiral silyloxypyroole 5 was prepared in two steps and its reaction with achiral aldehydes under Mukaiyama's reaction conditions was investigated. Addition occurred at the C-5 position of the pyrrolidine ring with complete Ut selectivity (except in the case of acetaldehyde) and a moderate to good diastereofacial (RR vs SS) selectivity.

引用

页码：1213 / 1216

页数：4

共 20 条

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