Non-FcR-binding, humanized anti-CD3 antibody Hu291 induces apoptosis of human T cells more effectively than OKT3 and is immunosuppressive in vivo

被引：6

作者：

Carpenter, PA

Tso, JY

Press, OW

Yu, XZ

Anasetti, C

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

[2] Prot Design Labs Inc, Fremont, CA USA

来源：

TRANSPLANTATION PROCEEDINGS | 2000年 / 32卷 / 07期

关键词：

D O I：

10.1016/S0041-1345(00)01343-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

[No abstract available]

引用

页码：1545 / 1546

页数：2

共 8 条

[1] TREATMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE WITH A NONMITOGENIC ANTI-CD3 MONOCLONAL-ANTIBODY [J].

ANASETTI, C ;

MARTIN, PJ ;

STORB, R ;

APPELBAUM, FR ;

BEATTY, PG ;

DAVIS, J ;

DONEY, K ;

HILL, HF ;

STEWART, P ;

SULLIVAN, KM ;

WITHERSPOON, RP ;

THOMAS, ED ;

HANSEN, JA .

TRANSPLANTATION, 1992, 54 (05) :844-851

[2]

ANASETTI C, 1990, J EXP MED, V172, P1692

[3] Activation and increased expression of adhesion molecules on peripheral blood lymphocytes is a mechanism for the immediate lymphocytopenia after administration of OKT3 [J].

Buysmann, S ;

Bemelman, FJ ;

Schellekens, PTA ;

vanKooyk, Y ;

Figdor, CG ;

tenBerge, IJM .

BLOOD, 1996, 87 (01) :404-411

[4]

COLE MS, 1999, TRANPLANTATION, V68, P647

[5] A humanized anti-CD3 antibody, HuM291, with low mitogenic activity, mediates complete and reversible T-cell depletion in chimpanzees [J].

Hsu, DH ;

Shi, JD ;

Homola, M ;

Rowell, TJ ;

Moran, J ;

Levitt, D ;

Druilhet, B ;

Chinn, J ;

Bullock, C ;

Klingbeil, C .

TRANSPLANTATION, 1999, 68 (04) :545-554

[6] T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs [J].

Smith, JA ;

Bluestone, JA .

CURRENT OPINION IN IMMUNOLOGY, 1997, 9 (05) :648-654

[7]

Yu XZ, 1996, J IMMUNOL, V157, P3420

[8]

ZHU LQ, 1995, J IMMUNOL, V154, P192

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