T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs

被引：54

作者：

Smith, JA

Bluestone, JA

机构：

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(97)80044-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pc receptor nonbinding anti-CD3 monoclonal antibodies show promise for clinical application, in that they suppress graft rejection without the toxicity associated with conventional anti-CD3 antibody therapy. Recent studies suggest that the mechanism of soluble anti-CD3 antibody mediated immunosuppression involves partial signaling, induced cytokine deviation and Th1 cell inactivation.

引用

页码：648 / 654

页数：7

共 39 条

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