T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs

被引：54

作者：

Smith, JA

Bluestone, JA

机构：

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(97)80044-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pc receptor nonbinding anti-CD3 monoclonal antibodies show promise for clinical application, in that they suppress graft rejection without the toxicity associated with conventional anti-CD3 antibody therapy. Recent studies suggest that the mechanism of soluble anti-CD3 antibody mediated immunosuppression involves partial signaling, induced cytokine deviation and Th1 cell inactivation.

引用

页码：648 / 654

页数：7

共 39 条

[31] Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
SloanLancaster, J
Allen, PM
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 : 1 - 27
[32] PARTIAL T-CELL SIGNALING - ALTERED PHOSPHO-ZETA AND LACK OF ZAP70 RECRUITMENT IN APL-INDUCED T-CELL ANERGY
SLOANLANCASTER, J
SHAW, AS
ROTHBARD, JB
ALLEN, PM
[J]. CELL, 1994, 79 (05) : 913 - 922
[33] INDUCTION OF T-CELL ANERGY BY ALTERED T-CELL-RECEPTOR LIGAND ON LIVE ANTIGEN-PRESENTING CELLS
SLOANLANCASTER, J
EVAVOLD, BD
ALLEN, PM
[J]. NATURE, 1993, 363 (6425) : 156 - 159
[34] Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy
Smith, JA
Tso, JY
Clark, MR
Cole, MS
Bluestone, JA
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (08) : 1413 - 1422
[35] The complexities of T-cell co-stimulation: CD28 and beyond
Sperling, AI
Bluestone, JA
[J]. IMMUNOLOGICAL REVIEWS, 1996, 153 : 155 - 182
[36] JNK IS INVOLVED IN SIGNAL INTEGRATION DURING COSTIMULATION OF T-LYMPHOCYTES
SU, B
JACINTO, E
HIBI, M
KALLUNKI, T
KARIN, M
BEN-NERIAH, Y
[J]. CELL, 1994, 77 (05) : 727 - 736
[37] VERWEIJ CL, 1991, J BIOL CHEM, V266, P14179
[38] T cell activation determined by T cell receptor number and tunable thresholds
Viola, A
Lanzavecchia, A
[J]. SCIENCE, 1996, 273 (5271) : 104 - 106
[39] SIGNAL-TRANSDUCTION BY LYMPHOCYTE ANTIGEN RECEPTORS
WEISS, A
LITTMAN, DR
[J]. CELL, 1994, 76 (02) : 263 - 274

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