T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs

被引:54
作者
Smith, JA
Bluestone, JA
机构
关键词
D O I
10.1016/S0952-7915(97)80044-1
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Pc receptor nonbinding anti-CD3 monoclonal antibodies show promise for clinical application, in that they suppress graft rejection without the toxicity associated with conventional anti-CD3 antibody therapy. Recent studies suggest that the mechanism of soluble anti-CD3 antibody mediated immunosuppression involves partial signaling, induced cytokine deviation and Th1 cell inactivation.
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页码:648 / 654
页数:7
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