Design of superconducting quantum interference device for magnetic immunoassays

被引：5

作者：

Enpuku, K ^{[1
]}

Ohba, AH ^{[1
]}

Inoue, K ^{[1
]}

Soejima, K ^{[1
]}

机构：

[1] Kyushu Univ, Res Inst Supercond Sci & Syst, Higashi Ku, Fukuoka 8128581, Japan

来源：

JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS | 2004年 / 43卷 / 9A期

关键词：

SQUID magnetometer; dipole field; pickup coil; magnetic nanoparticle; immunoassay;

D O I：

10.1143/JJAP.43.6044

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

A superconducting quantum interference device (SQUID) for application to biological immunoassays has been designed. In this application, the magnetic field from a magnetic marker made of magnetic nanoparticles is detected with the SQUID. It is shown that the conventional design of the SQUID that was developed for the case of uniform magnetic field cannot be used in this application, since the spatial variation of the magnetic field from the marker is large. Therefore, a numerical simulation method is developed for obtaining a signal flux detected with the SQUID when the magnetic field changes spatially. It is shown that the signal flux strongly depends on the geometrical parameters of the measurement system, such as the size of the pickup coil, size of the sample and the distance between the sample and the SQUID. The dependence of the signal flux on these geometrical parameters is quantitatively clarified, and the optimum design of the SQUID for the application to magnetic immunoassays is discussed.

引用

页码：6044 / 6049

页数：6

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