Caspase-1 inflammasomes in infection and inflammation

被引:153
作者
Lamkanfi, Mohamed
Kanneganti, Thirumala-Devi
Franchi, Luigi
Nunez, Gabriel
机构
[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI USA
关键词
NLR; TLR; ASC; Ipaf; cryopyrin;
D O I
10.1189/jlb.1206756
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Nucleotide-binding and oligomerization domain-like receptors (NLRs) constitute a family of germline-encoded pattern-recognition receptors, which allow the host to respond rapidly to a wide variety of pathogenic microorganisms. Here, we discuss recent advances in the study of a subset of NLRs, which control the activation of caspase-1 through the assembly of large protein complexes, inflammasomes. The NALP1b inflammasome recognizes anthrax lethal toxin, and flagellin from Salmonella and Legionella induces assembly of the Ipaf inflammasome. Cryopyrin/NALP3 mediates caspase-1 activation in response to a wide variety of bacterial ligands, imidazoquinolines, dsRNA, and the endogenous danger signal uric acid. The importance of these cytosolic receptors in immune regulation is underscored by the identification of mutations in cryopyrin/NALP3, which are genetically linked to human autoinflammatory disorders.
引用
收藏
页码:220 / 225
页数:6
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