Development of matrix-membrane transdermal drug delivery system for Atenolol

被引:17
作者
Gupta, SP
Jain, SK
机构
[1] Govt Coll Pharm, Aurangabad 431005, Maharashtra, India
[2] Dr Hari Singh Gour Vishwavidyalaya, Dept Pharmaceut Sci, Pharmaceut Res Project Lab, Sagar, India
关键词
Atenolol; eudragits RL; matrix diffusion controlled; transdermal delivery system; polyethylene glycol 4000; polyvinyl pyrrolidone;
D O I
10.1080/10717540490493943
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A polymer matrix system for transdermal delivery of Atenolol was developed for its prolonged and controlled release systemic availability. To achieve the desired and controlled release rate, different combinations of Eudragit RL with polyvinyl pyrrolidone and polyethylene glycol 4000 were used in the preparations of polymeric matrix system. These preparations were evaluated for in vitro release and permeation of the drug across pig skin. The desired systems exhibited linear relationship between drug release (Q) versus ne(0.8)(hr(0.8)). The product exhibiting required skin permeation 64 mcg/h/cm(2) to achieve an effective plasma concentration was selected for the in vivo performance evaluation. The drug plasma profile was compared with the plasma profile obtained following the administration of a conventional oral dose of Atenolol. The study revealed that the designed polymeric matrix transdermal drug delivery system of Atenolol could be successful with improved performance.
引用
收藏
页码:281 / 286
页数:6
相关论文
共 19 条
[1]  
BONDOR N, 1980, INT J PHARM, V7, P63
[3]   BIOAVAILABILITY OF PROPRANOLOL FOLLOWING ORAL AND TRANSDERMAL ADMINISTRATION IN RABBITS [J].
CORBO, M ;
LIU, JC ;
CHIEN, YW .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1990, 79 (07) :584-587
[4]  
Fitzpatrick J, 1993, DERMATOLOGY GEN MED
[6]  
HAUNG CY, 1985, DRUG DEV IND PHARM, V11, P1255
[7]   On the importance and mechanisms of burst release in matrix-controlled drug delivery systems [J].
Huang, X ;
Brazel, CS .
JOURNAL OF CONTROLLED RELEASE, 2001, 73 (2-3) :121-136
[8]   EVALUATION OF LANOLIN ALCOHOL FILMS AND KINETICS OF TRIAMCINOLONE ACETONIDE RELEASE [J].
IYER, BV ;
VASAVADA, RC .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1979, 68 (06) :782-787
[9]  
Jain G. K., 1993, Indian Journal of Experimental Biology, V31, P691
[10]  
PAGET GE, 1964, PHARMACOMETRICES, P155