T-cell memory: You must remember this ...

被引：16

作者：

Bevan, MJ ^{[1
]}

Goldrath, AW

机构：

[1] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

[2] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0960-9822(00)00461-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

While antigen-inexperienced (naive) T cells appear to require constant tickling of their receptor by self-antigens for homeostasis, antigen-experienced (memory)T cells have no such requirement. An implication is that long term T-cell memory does not depend on persisting antigen.

引用

收藏

页码：R338 / R340

页数：3

相关论文

共 13 条

[1] A direct estimate of the human αβ T cell receptor diversity [J].

Arstila, TP ;

Casrouge, A ;

Baron, V ;

Even, J ;

Kanellopoulos, J ;

Kourilsky, P .

SCIENCE, 1999, 286 (5441) :958-961

[2] The new numerology of immunity mediated by virus-specific CD8+ T cells [J].

Doherty, PC .

CURRENT OPINION IN MICROBIOLOGY, 1998, 1 (04) :419-422

[3] CD8+ T-CELL MEMORY TO VIRUSES [J].

DOHERTY, PC ;

HOU, S ;

TRIPP, RA .

CURRENT OPINION IN IMMUNOLOGY, 1994, 6 (04) :545-552

[4] Following the development of a CD4 T cell response in vivo: From activation to memory formation [J].

Garcia, S ;

DiSanto, J ;

Stockinger, B .

IMMUNITY, 1999, 11 (02) :163-171

[5] Selecting and maintaining a diverse T-cell repertoire [J].

Goldrath, AW ;

Bevan, MJ .

NATURE, 1999, 402 (6759) :255-262

[6] Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice [J].

Kennedy, MK ;

Glaccum, M ;

Brown, SN ;

Butz, EA ;

Viney, JL ;

Embers, M ;

Matsuki, N ;

Charrier, K ;

Sedger, L ;

Willis, CR ;

Brasel, K ;

Morrissey, PJ ;

Stocking, K ;

Schuh, JCL ;

Joyce, S ;

Peschon, JJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (05) :771-780

[7]

KU CC, 2000, IN PRESS SCIENCE

[8] IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation [J].

Lodolce, JP ;

Boone, DL ;

Chai, S ;

Swain, RE ;

Dassopoulos, T ;

Trettin, S ;

Ma, A .

IMMUNITY, 1998, 9 (05) :669-676

[9] Persistence of memory CD8 T cells in MHC class I-deficient mice [J].

Murali-Krishna, K ;

Lau, LL ;

Sambhara, S ;

Lemonnier, F ;

Altman, J ;

Ahmed, R .

SCIENCE, 1999, 286 (5443) :1377-1381

[10] Attrition of T cell memory: Selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses [J].

Selin, LK ;

Lin, MY ;

Kraemer, KA ;

Pardoll, DM ;

Schneck, JP ;

Varga, SM ;

Santolucito, PA ;

Pinto, AK ;

Welsh, RM .

IMMUNITY, 1999, 11 (06) :733-742