Increased microparticle tissue factor activity in cancer patients with Venous Thromboembolism

被引：171

作者：

Manly, David A. ^{[1
]}

Wang, Jianguo ^{[1
]}

Glover, Sam L. ^{[1
]}

Kasthuri, Raj ^{[1
]}

Liebman, Howard A. ^{[2
]}

Key, Nigel S. ^{[1
]}

Mackman, Nigel ^{[1
]}

机构：

[1] Univ N Carolina, Dept Med, Div Hematol Oncol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ So Calif, Keck Sch Med, Dept Med,Norris Comprehens Canc Ctr, Jane Anne Nohl Div Hematol, Los Angeles, CA 90033 USA

来源：

THROMBOSIS RESEARCH | 2010年 / 125卷 / 06期

关键词：

Tissue factor; Microparticles; Venous thrombosis; Cancer; FACTOR-POSITIVE MICROPARTICLES; PROCOAGULANT MICROPARTICLES; VIENNA CANCER; COAGULATION; ACTIVATION;

D O I：

10.1016/j.thromres.2009.09.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cancer patients exhibit a high rate of thromboembolism (VTE). In this study, we analyzed levels of microparticle (MP) tissue factor (TF) activity in cancer patients with or without VTE. Blood was collected from cancer patients within 24 h of objectively diagnosed VTE (n=53) and from cancer patients without VTE (n=13). MPs were isolated from platelet poor plasma by centrifugation at 20,000g for 15 min. MP TF activity was measured using a two-stage chromogenic assay. Cancer patients with VTE had a significantly higher mean MP TF activity compared with cancer patients without VTE (1.7 +/- 3.8 pg/mL vs 0.6 +/- 0.4 pg/mL, p<0.05). Further prospective studies are required to determine if levels of MP TF activity may be a useful biomarker to identify patients at increased risk for VTE. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：511 / 512

页数：2

共 19 条

[11] Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy [J].