Macrophages and Immunologic inflammation of the Kidney

被引：260

作者：

Duffield, Jeremy S. ^{[1
,2
,3
]}

机构：

[1] Brigham & Womens Hosp, Dept Med, Inflammat Res Lab, Div Renal, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Harvard Univ, Harvard Stem Cell Inst, Cambridge, MA 02138 USA

来源：

SEMINARS IN NEPHROLOGY | 2010年 / 30卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Macrophage; activation; injury; fibrosis; kidney; subpopulations; BASEMENT-MEMBRANE; BLOOD MONOCYTES; CRESCENTIC GLOMERULONEPHRITIS; GBM GLOMERULONEPHRITIS; PLASMINOGEN-ACTIVATOR; LEUKOCYTE RECRUITMENT; PULMONARY-FIBROSIS; GLOMERULAR INJURY; TUBULAR APOPTOSIS; IL-10; PRODUCTION;

D O I：

10.1016/j.semnephrol.2010.03.003

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

Monocyte-derived tissue effector cells, macrophages, are present in large numbers in all forms of kidney disease with inflammation. Their roles in inflammation and the molecular effectors of macrophage function have been difficult to decipher. With the advent of modern genetic tools and mouse models of human disease, great insight into monocyte/macrophage biology has been forthcoming. This review places macrophage study in its historical context, defines immunologic diseases of the kidney, broadens its definition to encompass current thinking of the immune response to kidney injury, highlights key advances of the study of monocyte/macrophages in kidney diseases, and identifies new therapeutic pathways and targets that hinge around macrophage function. This article advances the case that targeting macrophage activation and phenotype is leading to new therapies in the treatment of many acute and chronic kidney diseases. © 2010 Elsevier Inc.

引用

页码：234 / 254

页数：21

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