A contemporary understanding of progesterone receptor function

被引：61

作者：

Li, XT ^{[1
]}

Lonard, DM ^{[1
]}

O'Malley, BW ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Cell Biol, Houston, TX 77030 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2004年 / 125卷 / 10-11期

关键词：

progesterone receptor; transcription; mechanism; coactivators;

D O I：

10.1016/j.mad.2004.04.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Following the discovery of coactivators for nuclear receptors and the identification of a significant number of progesterone receptor (PR) target genes, our understanding of PR action has extended from its normally recognized functions to a wide variety of seemingly unlinked biological processes. Recent advances in defining the action of PR coactivators has revealed important mechanisms involving multiple layers of regulation in PR- mediated transcription. In this review, we will discuss the current understanding of PR physiology and the molecular basis of coactivator function in PR signaling events. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：669 / 678

页数：10

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