Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma

被引：47

作者：

Corthals, Sophie L. ^{[1
]}

Jongen-Lavrencic, Mojca ^{[1
]}

de Knegt, Yvonne ^{[1
]}

Peeters, Justine K. ^{[1
]}

Beverloo, H. Berna ^{[2
]}

Lokhorst, Henk M. ^{[3
]}

Sonneveld, Pieter ^{[1
]}

机构：

[1] Erasmus MC, Dept Hematol, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC, Dept Clin Genet, NL-3000 CA Rotterdam, Netherlands

[3] Univ Med Ctr Utrecht, Dept Hematol, Utrecht, Netherlands

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 05期

关键词：

Multiple myeloma; Micro-RNA; Chromosome; 13; deletion; POOR-PROGNOSIS; ABNORMALITIES; CYTOGENETICS; MICRORNAS; SURVIVAL; THERAPY; CELLS; 13Q14; FISH; PCR;

D O I：

10.1016/j.leukres.2009.10.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have used copy number variation (CNV) analysis with SNP mapping arrays for miRNA-15a and miRNA-16-1 expression analysis in patients with multiple myeloma (MM) with or without deletion of chromosome 13q14. MiRNA-15a and miRNA-16 display a range of expression patterns in MM patients, independent of the chromosome 13 status. These findings suggest that genes other than miR-15a and miR-16 may explain the prognostic significance of 13q14 deletions. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：677 / 681

页数：5

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