Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

被引：356

作者：

Vegiopoulos, Alexandros ^{[1
]}

Mueller-Decker, Karin ^{[2
]}

Strzoda, Daniela ^{[1
]}

Schmitt, Iris ^{[1
]}

Chichelnitskiy, Evgeny ^{[1
]}

Ostertag, Anke ^{[1
]}

Diaz, Mauricio Berriel ^{[1
]}

Rozman, Jan ^{[3
]}

de Angelis, Martin Hrabe ^{[3
]}

Nuesing, Rolf M. ^{[4
]}

Meyer, Carola W. ^{[5
]}

Wahli, Walter ^{[6
]}

Klingenspor, Martin ^{[7
]}

Herzig, Stephan ^{[1
]}

机构：

[1] German Canc Res Ctr DKFZ Heidelberg, Emmy Noether & Marie Curie Res Grp Mol Metab Cont, D-69120 Heidelberg, Germany

[2] German Canc Res Ctr DKFZ Heidelberg, Core Facil Tumor Models, DKFZ ZMBH Alliance, D-69120 Heidelberg, Germany

[3] Helmholtz Ctr Munich, Inst Expt Genet, D-85764 Neuherberg, Germany

[4] Goethe Univ Frankfurt, Inst Clin Pharmacol, D-60590 Frankfurt, Germany

[5] Univ Marburg, Dept Anim Physiol, D-35043 Marburg, Germany

[6] Univ Lausanne, Natl Res Ctr Frontiers Genet, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland

[7] Tech Univ Munich, Else Kroner Fresenius Ctr, D-85350 Freising Weihenstephan, Germany

来源：

SCIENCE | 2010年 / 328卷 / 5982期

关键词：

ADIPOSE-TISSUE; PPAR-GAMMA; IDENTIFICATION; RECEPTOR; FAT; CELECOXIB; OBESITY; PRDM16;

D O I：

10.1126/science.1186034

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Obesity results from chronic energy surplus and excess lipid storage in white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) efficiently burns lipids through adaptive thermogenesis. Studying mouse models, we show that cyclooxygenase (COX)-2, a rate-limiting enzyme in prostaglandin (PG) synthesis, is a downstream effector of beta-adrenergic signaling in WAT and is required for the induction of BAT in WAT depots. PG shifted the differentiation of defined mesenchymal progenitors toward a brown adipocyte phenotype. Overexpression of COX-2 in WAT induced de novo BAT recruitment in WAT, increased systemic energy expenditure, and protected mice against high-fat diet-induced obesity. Thus, COX-2 appears integral to de novo BAT recruitment, which suggests that the PG pathway regulates systemic energy homeostasis.

引用

页码：1158 / 1161

页数：4

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