Targeting the mitogen-activated protein kinase cascade to treat cancer

被引：949

作者：

Sebolt-Leopold, JS ^{[1
]}

Herrera, R ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Ann Arbor Labs, Mol Sci & Technol, Ann Arbor, MI 48105 USA

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 12期

关键词：

D O I：

10.1038/nrc1503

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The RAS-mitogen activated protein kinase (MAPK) signalling pathway has long been viewed as an attractive pathway for anticancer therapies, based on its central role in regulating the growth and survival of cells from a broad spectrum of human tumours. Small-molecule inhibitors designed to target various steps of this pathway have entered clinical trials. What have we recently learned about their safety and effectiveness? Will the MAPK pathway prove amenable to therapeutic intervention?

引用

页码：937 / 947

页数：11

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