The Expanding Universe of Cohesin Functions: A New Genome Stability Caretaker Involved in Human Disease and Cancer

被引：43

作者：

Mannini, Linda ^{[1
]}

Menga, Stefania ^{[1
]}

Musio, Antonio ^{[1
,2
]}

机构：

[1] CNR, Ist Tecnol Biomed, I-56100 Pisa, Italy

[2] Ist Toscano Tumori, Florence, Italy

来源：

HUMAN MUTATION | 2010年 / 31卷 / 06期

关键词：

cohesin; genome instability; cancer; Cornelia de Lange syndrome; Roberts syndrome; SISTER-CHROMATID COHESION; DE-LANGE-SYNDROME; ROBERTS-SYNDROME; NIPPED-B; SMC PROTEINS; GENE-EXPRESSION; HUMAN HOMOLOG; SEPARATION; MUTATIONS; COMPLEXES;

D O I：

10.1002/humu.21252

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cohesin is responsible for sister chromatid cohesion, ensuring the correct chromosome segregation. Beyond this role, cohesin and regulatory cohesin genes seem to play a role in preserving genuine stability and gene transcription regulation. DNA damage is thought to be a major culprit for many human diseases, including cancer. Our present knowledge of the molecular basis underlying genome instability is extremely limited. Mutations in cohesin genes cause human diseases such as Cornelia de Lange syndrome and Roberts syndrome/Sc phocomelia, and all the cell lines derived from affected patients show genome instability. Cohesin mutations have also been identified in colorectal cancer. Here, we will discuss the human disorders caused by alterations of cohesin function, with emphasis on the emerging role of cohesin as a genome stability caretaker. Hum Mutat 31:623-630, 2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：623 / 630

页数：8

共 103 条

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