AML with CBFB-MYH11 rearrangement demonstrate RAS pathway alterations in 92% of all cases including a high frequency of NF1 deletions

被引：50

作者：

Haferlach, C. ^{[1
]}

Dicker, F. ^{[1
]}

Kohlmann, A. ^{[1
]}

Schindela, S. ^{[1
]}

Weiss, T. ^{[1
]}

Kern, W. ^{[1
]}

Schnittger, S. ^{[1
]}

Haferlach, T. ^{[1
]}

机构：

[1] MLL Munich Leukemia Lab, Munich, Germany

来源：

LEUKEMIA | 2010年 / 24卷 / 05期

关键词：

ACUTE MYELOID-LEUKEMIA; GROUP-B; MUTATIONS; CANCER;

D O I：

10.1038/leu.2010.22

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1065 / 1069

页数：6

共 8 条

[1] Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias
Abbas, Saman
Rotmans, Gabrielle
Lowenberg, Bob
Valk, Peter J. M.
[J]. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 (10): : 1595 - 1597
[2] Implications of NRAS mutations in AML:: a study of 2502 patients
Bacher, Ulrike
Haferlach, Torsten
Schoch, Claudia
Kern, Wolfgang
Schnittger, Susanne
[J]. BLOOD, 2006, 107 (10) : 3847 - 3853
[3] Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia
Bullinger, Lars
Ruecker, Frank G.
Kurz, Stephan
Du, Juan
Scholl, Claudia
Sander, Sandrine
Corbacioglu, Andrea
Lottaz, Claudio
Froehling, Juergen
Ganser, Arnold
Schlenk, Richard F.
Doehner, Konstanze
Pollack, Jonathan R.
Doehner, Hartmut
[J]. BLOOD, 2007, 110 (04) : 1291 - 1300
[4] Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia
Castilla, LH
Perrat, P
Martinez, NJ
Landrette, SF
Keys, R
Oikemus, S
Flanegan, J
Heilman, S
Garrett, L
Dutra, A
Anderson, S
Pihan, GA
Wolff, L
Liu, PP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (14) : 4924 - 4929
[5] Nf1 deficiency cooperates with oncogenic K-RAS to induce acute myeloid leukemia in mice
Cutts, Briony A.
Sjogren, Anna-Karin M.
Andersson, Karin M. E.
Wahlstrom, Annika M.
Karlsson, Christin
Swolin, Birgitta
Bergo, Martin O.
[J]. BLOOD, 2009, 114 (17) : 3629 - 3632
[6] Molecular genetics of human leukemias: New insights into therapy
Gilliland, DG
[J]. SEMINARS IN HEMATOLOGY, 2002, 39 (04) : 6 - 11
[7] Patients with acute myeloid leukemia and RAS mutations benefit most from postremission high-dose cytarabine:: A Cancer and Leukemia Group B study
Neubauer, Andreas
Maharry, Kati
Mrozek, Krzysztof
Thiede, Christian
Marcucci, Guido
Paschka, Peter
Mayer, Robert J.
Larson, Richard A.
Liu, Edison T.
Bloomfield, Clara D.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (28) : 4603 - 4609
[8] Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21):: A Cancer and Leukemia Group B study
Paschka, Peter
Marcucci, Guido
Ruppert, Amy S.
Mrozek, Krzysztof
Chen, Hankui
Kittles, Rick A.
Vukosavljevic, Tamara
Perrotti, Danilo
Vardiman, James W.
Carroll, Andrew J.
Kolitz, Jonathan E.
Larson, Richard A.
Bloomfield, Clara D.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (24) : 3904 - 3911

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