Pleiotropic function of Toll-like receptors

被引：106

作者：

Kaisho, T

Akira, S

机构：

[1] Osaka Univ, Dept Host Defense, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan

[2] RIKEN, Res Ctr Allergy & Immunol, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

[3] Japan Sci & Technol Corp, Akira Innate Immun Project, ERATO, Suita, Osaka 5650871, Japan

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 15期

关键词：

Toll-like receptor; innate immunity; adaptive immunity; dendritic cells;

D O I：

10.1016/j.micinf.2004.08.019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A group of type I transmembrane proteins, Toll-like receptors (TLRs) discriminate various microorganism-associated molecular structures that can function as immune adjuvants. Each TLR signaling has an overlapping but distinct function, which largely depends on intracellular adaptor molecules. Clarifying the functions and signaling of TLRs should provide us with critical information for manipulating the host defense mechanism. (C) 2004 Elsevier SAS. All rights reserved.

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收藏

页码：1388 / 1394

页数：7

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