The cellular basis of albuminuria

被引：25

作者：

Mathieson, PW ^{[1
]}

机构：

[1] Southmead Gen Hosp, Acad Renal Unit, Bristol BS10 5NB, Avon, England

来源：

CLINICAL SCIENCE | 2004年 / 107卷 / 06期

关键词：

albuminuria; basement membrane; endothelial cell; glomerular filtration; nephrotic syndrome; podocyte; proteinuria;

D O I：

10.1042/CS20040168

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The appearance of albumin in the urine has long been recognized as a cardinal feature of kidney disease and more recently has been shown to also be an independent cardiovascular risk factor associated with insulin resistance. Recent studies on rare human genetic variants, targeted gene disruption in mouse models and cultured glomerular cells in vitro have dramatically improved our understanding of the cellular and molecular basis of albuminuria. This review aims to summarize the current state of knowledge, to illustrate known mechanisms of proteinuria in disease states and to suggest a possible explanation for the link between albuminuria and insulin resistance.

引用

页码：533 / 538

页数：6

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