Haemophilus influenzae meningitis 5 years after introduction of the Haemophilus influenzae type b conjugate vaccine in Brazil

被引：43

作者：

Ribeiro, Guilherme S.

Lima, Josilene B. T.

Reis, Joice N.

Gouveia, Edilane L.

Cordeiro, Soraia M.

Lobo, Tatiana S.

Pinheiro, Ricardo M.

Ribeiro, Cassio T.

Neves, Alan B.

Salgado, Katia

Silva, Hagamenon R.

Reis, Mitermayer G.

Ko, Albert I.

机构：

[1] Ministerio Saude, Fdn Oswaldo Cruz, Ctr Pesquisas Goncalo Moniz, BR-40296710 Salvador, BA, Brazil

[2] Univ Fed Bahia, Sch Pharm, Salvador, BA, Brazil

[3] Hosp Couto Maia, Secretary Hlth State Bahia, Salvador, BA, Brazil

[4] Univ Fed Bahia, Sch Med, Salvador, BA, Brazil

[5] Cornell Univ, Weill Med Coll, Dept Med, Div Int Med & Infect Dis, Ithaca, NY 14853 USA

来源：

VACCINE | 2007年 / 25卷 / 22期

关键词：

Haemophilus influenzae; vaccine effectiveness; serotype replacement;

D O I：

10.1016/j.vaccine.2007.03.024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The long-term impact of Haemophilus influenzae type b (Hib) conjugate vaccine, introduced throughout Latin America in the late 1990s, has not been evaluated. Active surveillance for H. influenzae meningitis was performed from August 9, 1996 to August 8, 2004 in Metropolitan Salvador, Brazil. Five years after the introduction of Hib conjugate vaccine, Hib meningitis incidence decreased from 2.39 to 0.06 cases per 100,000 population (98%) overall, and from 60.9 to 3.1 cases per 100,000 population (95%) in children <1 year of age. A transient serotype replacement phenomenon was observed associated with a small increase of meningitis due to two H. influenzae type a clonal groups. These findings indicate that Hib immunization campaign has led to the virtual elimination of Hib disease in this region. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4420 / 4428

页数：9