Bacterial ribosomal subunit assembly is an antibiotic target

被引:38
作者
Champney, WS [1 ]
机构
[1] E Tennessee State Univ, James H Quillen Coll Med, Dept Biochem & Mol Biol, Johnson City, TN 37614 USA
关键词
ribosomes; 30S ribosomal subunit; 50S ribosomal subunit; antibiotics; protein synthesis;
D O I
10.2174/1568026033452186
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A substantial number of antimicrobial agents target some activity of the bacteria] ribosome for inhibition. Mechanistic studies and recent structural investiga-tions of the ribosome have identified the binding sites and presumed mechanism of inhibitory activity for some compounds. A second target for many of these antibiotics has recently been examined. Formation of both 30S and 50S ribosonial subunits in bacterial cells is impaired by translational inhibitors. For many antimicrobial agents, inhibition of this target is equivalent to inhibition of translation in preventing cell growth. This review will describe features of this new target including the types of compounds which affect particle assembly and differences in the process in different microorganisms. The characteristics of this new target will be identified and aspects of a model to explain this new inhibitory activity will be explored.
引用
收藏
页码:929 / 947
页数:19
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