Y-chromosomal DNA haplotypes in infertile European males carrying Y-microdeletions

被引：26

作者：

Paracchini, S

Stuppia, L

Gatta, V

Palka, G

Moro, E

Foresta, C

Mengua, L

Oliva, R

Ballescà, JL

Kremer, JAM

van Golde, RJT

Tuerlings, JHAM

Hargreave, T

Ross, A

Cooke, H

Huellen, K

Vogt, PH

Tyler-Smith, C

机构：

[1] Univ Oxford, Dept Biochem, CRC, Chromosome Mol Biol Grp, Oxford OX1 3QU, England

[2] Univ G DAnnunzio, Dipartimento Sci Biomed, Sez Genet Med, Chieti, Italy

[3] CNR, Ist Citomorfol Umana Normale & Patol, Chieti, Italy

[4] Osped Civile, Serv Genet Umana, Pescara, Italy

[5] Univ Padua, Dept Med & Surg Sci, Padua, Italy

[6] Hosp Clin Barcelona, Genet Serv, Barcelona, Spain

[7] Hosp Clin Barcelona, Physiol Unit, Barcelona, Spain

[8] IDIBAPS, Inst Invest Biomed August Pi I Sunyer, Fac Med, Barcelona, Spain

[9] IGON, Inst Clin Ginecol Obstet & Neonatol, Assisted Reprod Unit, Barcelona, Spain

[10] Univ Nijmegen, Med Ctr, Dept Obstet & Gynaecol, Nijmegen, Netherlands

[11] Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands

[12] Univ Edinburgh, Dept Oncol, Edinburgh, Midlothian, Scotland

[13] Univ Edinburgh, MRC, Human Genet Unit, Edinburgh, Midlothian, Scotland

[14] Univ Heidelberg, Inst Humangenet, Heidelberg, Germany

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2000年 / 23卷 / 10期

关键词：

Y chromosome; haplotype; infertility; microdeletion; association study;

D O I：

10.1007/BF03343792

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have determined Y-chromosomal DNA haplotypes in 73 infertile European males carrying Y microdeletions and compared them with the haplotypes of 299 infertile males lacking microdeletions. Chromosomes were typed with a set of 11 binary Y markers, which identified 8 haplogroups in the sample. Haplogroup frequencies were compared between 3 microdeletion classes and the non-deleted infertile males. Deletions arise on many different haplotypic backgrounds. No statistically significant differences in frequency were seen, although the small number of AZFa deletions lay predominantly on one branch of the Y haplotype tree.(C) 2000, Editrice Kurtis.

引用

页码：671 / 676

页数：6

共 36 条

[1] MSY2:: a slowly evolving minisatellite on the human Y chromosome which provides a useful polymorphic marker in Chinese populations [J].