3′-ferrocene-labeled oligonucleotide chains end-tethered to gold electrode surfaces:: Novel model systems for exploring flexibility of short DNA using cyclic voltammetry

被引：169

作者：

Anne, A ^{[1
]}

Bouchardon, A ^{[1
]}

Moiroux, J ^{[1
]}

机构：

[1] Univ Paris 07, Electrochim Mol Lab, Unite Mixte Rech 7591, CNRS, F-75251 Paris 05, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 05期

关键词：

D O I：

10.1021/ja028640k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The flexibility of DNA is of central importance in biology, medicine, materials science, and mechanical engineering. In this study, we report an unprecedented electrochemical approach for investigating the flexibility of a short (typically 20-base), surface end-tethered single-stranded synthetic DNA oligonucleotide and of its postformed DNA duplex, taking as an example the homopolymer (dT)20 sequence in the regime of very high ionic strength (1∼ M). Copyright © 2003 American Chemical Society.

引用

页码：1112 / 1113

页数：2

共 29 条

[1] Andrieux C. P., 1986, INVESTIGATION RATE 2, P305
[2] Terminal attachment of polyethylene glycol (PEG) chains to a gold electrode surface. Cyclic voltammetry applied to the quantitative characterization of the flexibility of the attached PEG chains and of their penetration by mobile PEG chains
Anne, A
Demaille, C
Moiroux, J
[J]. MACROMOLECULES, 2002, 35 (14) : 5578 - 5586
[3] Elastic bounded diffusion. Dynamics of ferrocene-labeled poly(ethylene glycol) chains terminally attached to the outermost monolayer of successively self-assembled monolayers of immunoglobulins
Anne, A
Demaille, C
Moiroux, J
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (44) : 10379 - 10388
[4] Influence of intervening mismatches on long-range guanine oxidation in DNA duplexes
Bhattacharya, PK
Barton, JK
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (36) : 8649 - 8656
[5] Single-molecule studies of DNA mechanics
Bustamante, C
Smith, SB
Liphardt, J
Smith, D
[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY, 2000, 10 (03) : 279 - 285
[6] Force and kinetic barriers to unzipping of the DNA double helix
Cocco, S
Monasson, R
Marko, JF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (15) : 8608 - 8613
[7] Sequence dependent rigidity of single stranded DNA
Goddard, NL
Bonnet, G
Krichevsky, O
Libchaber, A
[J]. PHYSICAL REVIEW LETTERS, 2000, 85 (11) : 2400 - 2403
[8] HAGERMAN PJ, 1988, ANNU REV BIOPHYS BIO, V17, P265
[9] NEW CONCEPTS IN PROTEIN-DNA RECOGNITION - SEQUENCE-DIRECTED DNA BENDING AND FLEXIBILITY
HARRINGTON, RE
WINICOV, I
[J]. PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 47, 1994, 47 : 195 - 270
[10] Electrochemical study of electron transport through thin DNA films
Hartwich, G
Caruana, DJ
de Lumley-Woodyear, T
Wu, YB
Campbell, CN
Heller, A
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (46) : 10803 - 10812

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