An efficient, three-component synthesis of isoindolin-1-one-3-phosphonates under mild and solvent-free conditions

被引：23

作者：

Adib, Mehdi ^{[1
]}

Sheikhi, Ehsan ^{[1
]}

Yazzaf, Rozita ^{[1
]}

Bijanzadeh, Hamid Reza ^{[2
]}

Mirzaei, Peiman ^{[3
]}

机构：

[1] Univ Tehran, Coll Sci, Sch Chem, POB 14155-6455, Tehran, Iran

[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

[3] Shahid Beheshti Univ, Dept Chem, Tehran, Iran

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 08期

基金：

美国国家科学基金会;

关键词：

Multi-component reactions; Isoindolin-l-one-3-phosphonates; 2-Formylbenzoic acids; Primary amines; Trialkyl phosphites; Solvent-free synthesis; HIGHLY DIASTEREOSELECTIVE SYNTHESIS; ONE-POT SYNTHESIS; FUNCTIONALIZED ISOINDOLINONES; STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; DERIVATIVES; ACID; CYCLIZATION; MOIETY;

D O I：

10.1016/j.tetlet.2015.12.055

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

An efficient and mild three-component synthesis of isoindolin-1-one-3-phosphonates is described. The reaction between a 2-formylbenzoic acid, a primary amine, and a trialkyl phosphite proceeded at ambient temperature under catalyst-and solvent-free conditions to afford the desired compounds in excellent yields. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：841 / 844

页数：4

共 46 条

[1]

Solvent-free and three-component synthesis of 1H,6H-6λ5-[1,2]benzoxaphospholo[2,3-b][1,2]benzoxaphosphol-1-ones [J].