Interleukin-18: A therapeutic target in rheumatoid arthritis? Commentary

被引：48

作者：

McInnes, IB ^{[1
]}

Liew, FY ^{[1
]}

Gracie, JA ^{[1
]}

机构：

[1] Univ Glasgow, Div Immunol, Infection & Inflammation, Glasgow G12 8QQ, Lanark, Scotland

来源：

ARTHRITIS RESEARCH & THERAPY | 2005年 / 7卷 / 01期

关键词：

cytokine; IL-18; inflammation rheumatoid arthritis;

D O I：

10.1186/ar1497

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin 18 (IL-18), a member of the IL-1 superfamily of cytokines has been demonstrated to be an important mediator of both innate and adaptive immune responses. Several reports have implicated its role in the pathogenesis of rheumatoid arthritis (RA). Although biologic therapy is firmly established in the treatment of a number of inflammatory diseases including RA, partial and non-responder patients constitute residual unmet clinical need. The aim of this article is to briefly review the biology of, and experimental approaches to IL-18 neutralisation, together with speculation as to the relative merits of IL-18 as an alternative to existing targets.

引用

页码：38 / 41

页数：4

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