Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription

被引：232

作者：

Galarneau, L

Nourani, A

Boudreault, AA

Zhang, Y

Héliot, L

Allard, S

Savard, J

Lane, WS

Stillman, DJ

Côté, J

机构：

[1] Univ Laval, Hotel Dieu, Canc Res Ctr, CHUQ, Quebec City, PQ G1R 2J6, Canada

[2] Univ Utah, Hlth Sci Ctr, Dept Oncol Sci, Salt Lake City, UT 84132 USA

[3] Harvard Univ, Harvard Microchem Facil, Cambridge, MA 02138 USA

来源：

MOLECULAR CELL | 2000年 / 5卷 / 06期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

D O I：

10.1016/S1097-2765(00)80258-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NuA4 is an essential histone H4/H2A acetyltransferase complex that interacts with activators and stimulates transcription in vitro. We have identified three novel NuA4 subunits: Act3/Arp4, an actin-related protein implicated in epigenetic control of transcription, Act1, and EpI1, a protein homologous to Drosophila Enhancer of Polycomb. Act3/Arp4 binds nucleosomes in vitro and is required for NuA4 integrity in vivo. Mutations in ACT3 and acetyltransferase-encoding ESA1 cause gene-specific transcription defects. Accordingly, NuA4 is localized in precise loci within the nucleus and does not overlap with the silent chromatin marker Sir3. These data along with the known epigenetic roles of Act3/Arp4 and homologs of EpI2 and Esa1 strongly support an essential role for chromatin structure modification by NuA4 in transcription regulation in vivo.

引用

页码：927 / 937

页数：11

共 54 条

[1] NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p [J].