Detection of an endogenous cannabimimetic molecule, 2-arachidonoylglycerol, and cannabinoid CB1 receptor mRNA in human vascular cells: Is 2-arachidonoylglycerol a possible vasomodulator?

被引：128

作者：

Sugiura, T ^{[1
]}

Kodaka, T ^{[1
]}

Nakane, S ^{[1
]}

Kishimoto, S ^{[1
]}

Kondo, S ^{[1
]}

Waku, K ^{[1
]}

机构：

[1] Teikyo Univ, Fac Pharmaceut Sci, Sagamiko, Kanagawa 19901, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 243卷 / 03期

关键词：

D O I：

10.1006/bbrc.1998.8187

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human vascular endothelial cells were found to generate and release 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, upon stimulation with thrombin or A23187. We confirmed that vascular smooth muscle cells as well as endothelial cells possess cannabinoid CB1 receptor mRNA. 2-Arachidonoylglycerol, generated in vascular tissues, may play an important role in modulating vascular tone through acting on the cannabinoid CB1 receptor expressed on vascular smooth muscle cells, endothelial cells as well as peripheral nerve terminals. (C) 1998 Academic Press.

引用

页码：838 / 843

页数：6

共 35 条

[1] [Anonymous], CANNABINOID RECEPTOR
[2] Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells
Bisogno, T
Sepe, N
Melck, D
Maurelli, S
DePetrocellis, L
DiMarzo, V
[J]. BIOCHEMICAL JOURNAL, 1997, 322 : 671 - 677
[3] BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
[4] CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
[5] Production and physiological actions of anandamide in the vasculature of the rat kidney
Deutsch, DG
Goligorsky, MS
Schmid, PC
Krebsbach, RJ
Schmid, HHO
Das, SK
Dey, SK
Arreaza, G
Thorup, C
Stefano, G
Moore, LC
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (06) : 1538 - 1546
[6] DEVANE WA, 1988, MOL PHARMACOL, V34, P605
[7] ISOLATION AND STRUCTURE OF A BRAIN CONSTITUENT THAT BINDS TO THE CANNABINOID RECEPTOR
DEVANE, WA
HANUS, L
BREUER, A
PERTWEE, RG
STEVENSON, LA
GRIFFIN, G
GIBSON, D
MANDELBAUM, A
ETINGER, A
MECHOULAM, R
[J]. SCIENCE, 1992, 258 (5090) : 1946 - 1949
[8] DIMARZO V, 1998, IN PRESS BIOCHEMISTR
[9] Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat
Felder, CC
Nielsen, A
Briley, EM
Palkovits, M
Priller, J
Axelrod, J
Nguyen, DN
Richardson, JM
Riggin, RM
Koppel, GA
Paul, SM
Becker, GW
[J]. FEBS LETTERS, 1996, 393 (2-3) : 231 - 235
[10] BRADYKININ STIMULATES PHOSPHOINOSITIDE HYDROLYSIS AND MOBILIZATION OF ARACHIDONIC-ACID IN DORSAL-ROOT GANGLION NEURONS
GAMMON, CM
ALLEN, AC
MORELL, P
[J]. JOURNAL OF NEUROCHEMISTRY, 1989, 53 (01) : 95 - 101

← 1 2 3 4 →