Detection of an endogenous cannabimimetic molecule, 2-arachidonoylglycerol, and cannabinoid CB1 receptor mRNA in human vascular cells: Is 2-arachidonoylglycerol a possible vasomodulator?

被引：128

作者：

Sugiura, T ^{[1
]}

Kodaka, T ^{[1
]}

Nakane, S ^{[1
]}

Kishimoto, S ^{[1
]}

Kondo, S ^{[1
]}

Waku, K ^{[1
]}

机构：

[1] Teikyo Univ, Fac Pharmaceut Sci, Sagamiko, Kanagawa 19901, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 243卷 / 03期

关键词：

D O I：

10.1006/bbrc.1998.8187

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human vascular endothelial cells were found to generate and release 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, upon stimulation with thrombin or A23187. We confirmed that vascular smooth muscle cells as well as endothelial cells possess cannabinoid CB1 receptor mRNA. 2-Arachidonoylglycerol, generated in vascular tissues, may play an important role in modulating vascular tone through acting on the cannabinoid CB1 receptor expressed on vascular smooth muscle cells, endothelial cells as well as peripheral nerve terminals. (C) 1998 Academic Press.

引用

页码：838 / 843

页数：6

共 35 条

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