Piribedil-induced sleep attacks in Parkinson's disease

被引：18

作者：

Tan, EK ^{[1
]}

机构：

[1] Singapore Gen Hosp, Dept Neurol, Parkinsons Dis & Movement Disorder Programme, Singapore 169608, Singapore

来源：

FUNDAMENTAL & CLINICAL PHARMACOLOGY | 2003年 / 17卷 / 01期

关键词：

Piribedil; sleep attacks; Parkinson's disease;

D O I：

10.1046/j.1472-8206.2003.00122.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

'Sleep attacks', episodes of sudden onset of sleep without any prodromal symptoms, were initially described in patients with Parkinson's disease (PD) taking the newer dopamine agonists pramipexole and ropinirole. Piribedil, a nonergot agonist with both D2 and D3 agonist action, is an effective antiparkinsonian medication. However, there are very few reports of Piribedil-induced sleep attacks in PD. Among 50 PD patients seen at our Movement Disorder Clinic who had recently taken Piribedil, we identified three (6%) who satisfied the clinical description of sleep attacks. Here we provide details of the clinical characteristics of Piribedil-induced sleep attacks in these PD patients.

引用

页码：117 / 119

页数：3

共 20 条

[1] Increased risk of somnolence with the new dopamine agonists in patients with Parkinson's disease - A meta-analysis of randomised controlled trials [J].