Recent advances in electrochemical DNA hybridization sensors

被引:105
作者
Hvastkovs, Eli G. [1 ]
Buttry, Daniel A. [2 ]
机构
[1] E Carolina Univ, Dept Chem, Greenville, NC 27858 USA
[2] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA
关键词
SEQUENCE-SPECIFIC DETECTION; NUCLEIC-ACIDS; FERROCENYLNAPHTHALENE DIIMIDE; POTENTIOMETRIC DETECTION; SENSITIVE DETECTION; CHARGE-TRANSFER; BLOOD-SERUM; BIOSENSOR; AMPLIFICATION; PEPTIDE;
D O I
10.1039/c0an00113a
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Even with the advent of industry produced electrochemical DNA analysis chips, electrochemical DNA hybridization detection continues to be an intensive research focus area. The advantages of electrochemical detection continue to inspire efforts to improve selectivity and sensitivity. Here, we summarize the landscape of recent efforts in electrochemical DNA hybridization detection. We specifically focus on some main areas from where novel work continues to originate: redox active molecules designed for specific interaction with double stranded DNA, DNA mimics to eliminate background electrochemical signals, external nanoparticle or enzyme modifications for sensitivity enhancements, split and self-hybridizing single stranded DNA probe modifications, and novel catalytic oxidation techniques. Additionally, we touch on the use of DNA hybridization sensors to monitor alternative biochemical (non-DNA hybridization) processes.
引用
收藏
页码:1817 / 1829
页数:13
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