Master equation approach to protein folding and kinetic traps

被引：78

作者：

Cieplak, M

Henkel, M

Karbowski, J

Banavar, JR

机构：

[1] Polish Acad Sci, Inst Phys, PL-02668 Warsaw, Poland

[2] Univ Henri Poincare Nancy 1, Phys Mat Lab, F-54506 Vandoeuvre Nancy, France

[3] Boston Univ, Dept Phys, Ctr Polymer Studies, Boston, MA 02215 USA

[4] Penn State Univ, Dept Phys, University Pk, PA 16802 USA

[5] Penn State Univ, Ctr Phys Mat, University Pk, PA 16802 USA

来源：

PHYSICAL REVIEW LETTERS | 1998年 / 80卷 / 16期

关键词：

D O I：

10.1103/PhysRevLett.80.3654

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The master equation for 12-monomer lattice heteropolymers is solved numerically and the time evolution of the occupancy of the native state is determined. At low temperatures, the median folding time follows the Arrhenius law and is governed by the longest relaxation time. For good folders significant kinetic traps appear in the folding funnel, whereas for bad folders the traps also occur in non-native energy valleys.

引用

页码：3654 / 3657

页数：4

共 22 条

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