Metronidazole-induced encephalopathy

被引：52

作者：

Kim, DW

Park, JM

Yoon, BW

Baek, MJ

Kim, JE

Kim, SY

机构：

[1] Seoul Natl Univ, Bundang Hosp, Dept Neurol, Clin Neurosci Ctr, Seongnam 464707, Gyeonggi Do, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Neurol, Seoul, South Korea

[3] Eulji Univ, Sch Med, Dept Neurol, Eulji Gen Hosp, Seoul, South Korea

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2004年 / 224卷 / 1-2期

关键词：

metronidazole; encephalopathy; magnetic resonance imaging;

D O I：

10.1016/j.jns.2004.06.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report the clinical, neuropsychological, and neuroimaging findings of two patients of diffuse encephalopathy associated with the use of metronidazole. Both patients showed characteristic abnormalities on magnetic resonance imaging (MRI) with diffusion weighted imaging (DWI) and recovered incompletely after the discontinuation of metronidazole. We also suggest that MRI with DWI may be useful in the diagnosis of metronidazole-induced encephalopathy, and that they have a role in the prediction of prognosis. (C) 2004 Elsevier B.V. All rights reserved.

引用

收藏

页码：107 / 111

页数：5

相关论文

共 24 条

[1] REVERSIBLE MAGNETIC-RESONANCE-IMAGING FINDINGS IN METRONIDAZOLE-INDUCED ENCEPHALOPATHY [J].

AHMED, A ;

LAES, DJ ;

BRESSLER, EL .

NEUROLOGY, 1995, 45 (03) :588-589

[2] Metronidazole-induced encephalopathy in a uremic patient: A case report [J].

Arik, N ;

Cengiz, N ;

Bilge, A .

NEPHRON, 2001, 89 (01) :108-109

[3] Convulsions induced by metronidazole treatment for Clostridium difficile-associated disease in chronic renal failure [J].

Beloosesky, Y ;

Grosman, B ;

Marmelstein, V ;

Grinblat, J .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2000, 319 (05) :338-339

[4] METRONIDAZOLE NEUROPATHY [J].

BRADLEY, WG ;

KARLSSON, IJ ;

RASSOL, CG .

BRITISH MEDICAL JOURNAL, 1977, 2 (6087) :610-611

[5] Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy [J].

Cecil, KM ;

Halsted, MJ ;

Schapiro, M ;

Dinopoulos, A ;

Jones, BV .

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 2002, 26 (06) :948-951

[6] Diffusion-weighted Imaging abnormalities in Wernicke encephalopathy - Reversible cytotoxic edema? [J].

Chu, K ;

Kang, DW ;

Kim, HJ ;

Lee, YS ;

Park, SH .

ARCHIVES OF NEUROLOGY, 2002, 59 (01) :123-127

[7] METRONIDAZOLE NEUROPATHY [J].

COXON, A ;

PALLIS, CA .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1976, 39 (04) :403-405

[8] APPARENT DIFFUSION-COEFFICIENT MAPPING OF EXPERIMENTAL FOCAL CEREBRAL-ISCHEMIA USING DIFFUSION-WEIGHTED ECHO-PLANAR IMAGING [J].

DARDZINSKI, BJ ;

SOTAK, CH ;

FISHER, M ;

HASEGAWA, Y ;

LI, LM ;

MINEMATSU, K .

MAGNETIC RESONANCE IN MEDICINE, 1993, 30 (03) :318-325

[9] Diffusion-weighted MRI in cyclosporin A neurotoxicity for the classification of cerebral edema [J].

Debaere, C ;

Stadnik, T ;

De Maeseneer, M ;

Osteaux, M .

EUROPEAN RADIOLOGY, 1999, 9 (09) :1916-1918

[10] Diffusion-weighted MR imaging in the brain in children:: Findings in the normal brain and in the brain with white matter diseases [J].

Engelbrecht, V ;

Scherer, A ;

Rassek, M ;

Witsack, HJ ;

Mödder, U .

RADIOLOGY, 2002, 222 (02) :410-418