Genetic characterization of breast cancer and implications for clinical management

被引：24

作者：

Geyer, Felipe C. ^{[1
]}

Lopez-Garcia, Maria A. ^{[1
]}

Lambros, Maryou B. ^{[1
]}

Reis-Filho, Jorge S. ^{[1
]}

机构：

[1] Inst Canc Res, Breakthrough Breast Canc Res Ctr, Mol Pathol Lab, London SW3 6JB, England

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2009年 / 13卷 / 10期

关键词：

microarray; comparative genomic hybridization; gene expression; biomarker; therapeutic target; TOPOISOMERASE-II-ALPHA; IN-SITU HYBRIDIZATION; COPY NUMBER ALTERATIONS; TRIPLE-NEGATIVE TUMORS; BASAL-LIKE SUBTYPE; DNA-REPAIR DEFECT; ESTROGEN-RECEPTOR; E-CADHERIN; ADJUVANT CHEMOTHERAPY; LOBULAR CARCINOMA;

D O I：

10.1111/j.1582-4934.2009.00906.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Breast cancer is a genetic disease caused by the accumulation of mutations in neoplastic cells. In the last few years, high-throughput microarray-based molecular analysis has provided increasingly more coherent information about the genetic aberrations in breast cancer. New biomarkers and molecular techniques are slowly becoming part of the diagnostic and prognostic armamentarium available for pathologists and oncologists to tailor the therapy for breast cancer patients. In this review, we will focus on the contribution of breast cancer somatic genetics to our understanding of breast cancer biology and its impact on breast cancer patient management.

引用

页码：4090 / 4103

页数：14

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