Checkpoints: How to activate p53

被引：155

作者：

Caspari, T ^{[1
]}

机构：

[1] Univ Sussex, MRC, Cell Mutat Unit, Brighton BN1 9RR, E Sussex, England

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0960-9822(00)00439-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20.

引用

页码：R315 / R317

页数：3

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