Polyhydroxy amino acid derivatives via β-lactams using enantiospecific approaches and microwave techniques

被引：82

作者：

Bose, AK ^{[1
]}

Banik, BK ^{[1
]}

Mathur, C ^{[1
]}

Wagle, DR ^{[1
]}

Manhas, MS ^{[1
]}

机构：

[1] Stevens Inst Technol, Dept Chem & Chem Technol, George Barasch Biorgan Res Lab, Hoboken, NJ 07030 USA

来源：

TETRAHEDRON | 2000年 / 56卷 / 31期

关键词：

annulation; azetidinones; enantiospecific; amino sugars; amino acids; microwave irradiation;

D O I：

10.1016/S0040-4020(00)00410-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiospecific synthesis has been developed for alpha-hydroxy beta-lactams of predictable absolute configuration starting with readily available carbohydrates, Stereospecific approaches and microwave assisted chemical reactions have been utilized for the preparation of these 3-hydroxy-2-azetidinones and their conversion to natural or non-natural enantiomeric forms of intermediates for gentosamine, 6-epilincosamine, gamma-hydroxythreonine, and polyoxamic acid. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5603 / 5619

页数：17

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