Endothelin-1: a multifunctional molecule in cancer

被引：140

作者：

Grant, K ^{[1
]}

Loizidou, M ^{[1
]}

Taylor, I ^{[1
]}

机构：

[1] Royal Free & UCL, Sch Med, Dept Surg, London W1W 7EJ, England

来源：

BRITISH JOURNAL OF CANCER | 2003年 / 88卷 / 02期

关键词：

endothelin-1; cancer; angiogenesis; tumour growth; apoptosis;

D O I：

10.1038/sj.bjc.6700750

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Endothelin-1 is a small vasoconstrictor peptide that was first identified in 1988. Here we review the evidence implicating ET-1 in tumorigenesis. In particular, we concentrate on the role of ET-1 in mitogenesis, apoptosis, angiogenesis, tumour invasion and metastasis, and discuss the potential for endothelin-system modulation as an adjuvant therapeutic strategy.

引用

页码：163 / 166

页数：4

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