Nature of the working memory deficit in Fragile-X syndrome

被引：82

作者：

Munir, F

Cornish, KM

Wilding, J

机构：

[1] Univ Nottingham, Sch Med, Div Psychiat, Sect Dev Psychiat, Nottingham NG7 2UH, England

[2] Univ London, Royal Holloway & Bedford New Coll, Dept Psychol, Egham TW20 0EX, Surrey, England

来源：

BRAIN AND COGNITION | 2000年 / 44卷 / 03期

关键词：

working memory; fragile-X syndrome; phonological memory; visuospatial memory; executive skills;

D O I：

10.1006/brcg.1999.1200

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Working memory performance in a group of young Fragile X males with FMR-1 full mutation was compared to a learning disabled comparison group comprising Down's syndrome males and two control groups of mainstream schoolchildren. Performance was assessed on a battery of tasks tapping the three components of working memory-phonological loop, visual-spatial sketch pad, and the central executive. The results indicated that the Fragile X group displayed a general impairment on working memory tasks that cannot be attributed to a single working memory component per se. Instead, the results suggest that Fragile X males have a working memory deficit that may be attributed to how much attentional resource a specific task requires and their overall available executive capacity, irrespective of the working memory subsystem. (C) 2000 Academic Press.

引用

页码：387 / 401

页数：15