Grip strength and cardiovascular drug use in older people: findings from the Hertfordshire Cohort Study

被引：38

作者：

Ashfield, T. A.

Syddall, H. E. ^{[1
]}

Martin, H. J. ^{[1
]}

Dennison, E. M. ^{[1
]}

Cooper, C. ^{[1
]}

Sayer, A. Aihie ^{[1
]}

机构：

[1] Univ Southampton, MRC, Epidemiol Resource Ctr, Southampton SO16 6YD, Hants, England

来源：

AGE AND AGEING | 2010年 / 39卷 / 02期

基金：

英国医学研究理事会;

关键词：

grip strength; sarcopenia; cardiovascular drugs; ageing; elderly; MUSCLE STRENGTH; PHYSICAL FUNCTION; STATIN USE; ASSOCIATION; WOMEN; FALLS;

D O I：

10.1093/ageing/afp203

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Methods: we investigated associations between cardiovascular drug use and grip strength among 1,572 men and 1,415 women, aged 59-73, who participated in the Hertfordshire Cohort Study. Results: Forty-five percent of participants were taking a cardiovascular drug. Furosemide was associated with average decreases in grip strength of 3.15 kg (95% confidence interval [CI] 0.90, 5.39, P < 0.01) among men and 2.35 kg (95% CI 0.93, 3.77, P < 0.01) among women after adjustment for age and height. Corresponding differences for nitrates were 1.84 kg (95% CI 0.29, 3.39, P = 0.02) among men and 3.66 kg (95% CI 1.99, 5.33, P < 0.01) among women. Calcium channel blockers and fibrates were associated with reduced grip among women. Statins were not associated with grip. The associations between grip strength and nitrate use in men and nitrate and fibrate use in women were robust to additional adjustment for co-morbidity. Conclusions: use of some cardiovascular drugs is associated with reduced grip strength in older people. These findings have potential implications for the functional ability of older people treated with these drugs.

引用

页码：185 / 191

页数：7

共 34 条

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