Delayed neurotrophin treatment supports auditory neuron survival in deaf guinea pigs

被引：76

作者：

Gillespie, LN

Clark, GM

Marzella, PL

机构：

[1] Univ Melbourne, Eye & Ear Hosp, Dept Otolaryngol, Melbourne, Vic, Australia

[2] Bion Ear Inst, Melbourne, Vic 3002, Australia

来源：

NEUROREPORT | 2004年 / 15卷 / 07期

关键词：

delayed treatment; neurotrophin; SGN survival;

D O I：

10.1097/00001756-200405190-00008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

As key factors in the development and maintenance of the auditory system, neurotrophins can prevent auditory neuron degeneration when applied within three to five days of deafening. We tested each of the neurotrophins BDNF, NT-3, NT-4/5 and NGF for their ability to support auditory neuron survival following a two-week period of deafness in guinea pigs, when similar to15% auditory neuron degeneration has already occurred. Although delayed, the treatment with each neurotrophin prevented further degeneration with similar efficacy.

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收藏

页码：1121 / 1125

页数：5

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