Asymmetric amine-intercepted nazarov cyclization

被引：68

作者：

Dhoro, Francis

Kristensen, Tor E.

Stockmann, Vegar

Yap, Glenn P. A.

Tius, Marcus A.

机构：

[1] Univ Hawaii, Dept Chem, Honolulu, HI 96822 USA

[2] Univ Delaware, Newark, DE 19716 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 23期

关键词：

D O I：

10.1021/ja0718873

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The chiral auxiliary directed addition of a propargyllithium reagent to a morpholino enamide, followed by exposure of the adduct to activated dry Florisil in the absence of solvent and in the presence of a primary or secondary amine, leads to a cascade of reactions that results in the formation of an aminocyclopentenone as a single diastereoisomer. The reaction can also be conducted intramolecularly.

引用

页码：7256 / +

页数：3

共 19 条

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