Apoptosis inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus

被引：45

作者：

Bhutani, K. K. ^{[1
]}

Paul, A. T. ^{[1
]}

Fayad, W. ^{[2
]}

Linder, S. ^{[2
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Nat Prod, Mohali 160062, Punjab, India

[2] Karolinska Hosp & Inst, Canc Ctr Karolinska, Dept Pathol & Oncol, Stockholm, Sweden

来源：

PHYTOMEDICINE | 2010年 / 17卷 / 10期

关键词：

Anticancer activity; Apoptosis; Sarsapogenin and Diosgenin derived steroidal constituents; Glycoalkaloids; Solanum xanthocarpum; Asparagus racemosus; HEPG2; CELLS; RATS; SOLAMARGINE; EXTRACT; PLANTS; ROOTS; DEATH;

D O I：

10.1016/j.phymed.2010.01.017

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A series of Sarsapogenin and Diosgenin derived steroidal constituents (1-12), isolated from Solanum xanthocarpum and Asparagus racemosus were screened for their ability to induce cell death and apoptosis of colon carcinoma cells. The carbohydrate moieties linked to the steroid backbones were found to strongly influence cytotoxic activity and cell death mode (apoptosis or necrosis). Compound 10, from A. racemosus was found to be a potent inducer of apoptosis. (C) 2010 Elsevier GmbH. All rights reserved.

引用

页码：789 / 793

页数：5

共 30 条

[1] Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component [J].

Attele, AS ;

Zhou, YP ;

Xie, JT ;

Wu, JA ;

Zhang, L ;

Dey, L ;

Pugh, W ;

Rue, PA ;

Polonsky, KS ;

Yuan, CS .

DIABETES, 2002, 51 (06) :1851-1858

[2]

Bector N P, 1971, J Assoc Physicians India, V19, P741

[3] Solanine-S [J].

Briggs, LH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1937, 59 :1404-1405

[4] The rhamnose moiety of solamargine plays a crucial role in triggering cell death by apoptosis [J].

Chang, LC ;

Tsai, TR ;

Wang, JJ ;

Lin, CN ;

Kuo, KW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 242 (01) :21-25

[5]

Corbiere C, 2003, INT J ONCOL, V22, P899

[6] Plants as a source of anti-cancer agents [J].

Cragg, GM ;

Newman, DJ .

JOURNAL OF ETHNOPHARMACOLOGY, 2005, 100 (1-2) :72-79

[7] Antifungal potential of Indian medicinal plants [J].

Dabur, R ;

Singh, H ;

Chhillar, AK ;

Ali, M ;

Sharma, GL .

FITOTERAPIA, 2004, 75 (3-4) :389-391

[8] Immunoprotection by botanical drugs in cancer chemotherapy [J].

Diwanay, S ;

Chitre, D ;

Patwardhan, B .

JOURNAL OF ETHNOPHARMACOLOGY, 2004, 90 (01) :49-55

[9] A pilot study on the clinical efficacy of Solanum xanthocarpum and Solanum trilobatum in bronchial asthma [J].

Govindan, S ;

Viswanathan, S ;

Vijayasekaran, V ;

Alagappan, R .

JOURNAL OF ETHNOPHARMACOLOGY, 1999, 66 (02) :205-210

[10] Structural revision of shatavarins I and IV, the major components from the roots of Asparagus racemosus [J].

Hayes, Patricia Y. ;

Jahidin, Aisyah Hasyila ;

Lehmann, Reg ;

Penman, Kerry ;

Kitching, William ;

De Voss, James J. .

TETRAHEDRON LETTERS, 2006, 47 (39) :6965-6969

← 1 2 3 →