The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation

被引：253

作者：

Kilian, B

Mansukoski, H

Barbosa, FC

Ulrich, F

Tada, M

Heisenberg, CP

机构：

[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany

[2] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England

来源：

MECHANISMS OF DEVELOPMENT | 2003年 / 120卷 / 04期

基金：

英国医学研究理事会;

关键词：

Wnt signalling; convergent extension; gastrulation; zebrafish;

D O I：

10.1016/S0925-4773(03)00004-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wnt genes play important roles in regulating patterning and morphogenesis during vertebrate gastrulation. In zebrafish, slb/wnt11 is required for convergence and extension movements, but not cell fate specification during gastrulation. To determine if other Wnt genes functionally interact with slb/wnt11, we analysed the role of ppt/wnt5 during zebrafish gastrulation. ppt/wnt5 is maternally provided and zygotically expressed at all stages during gastrulation. The analysis of ppt mutant embryos reveals that Ppt/Wnt5 regulates cell elongation and convergent extension movements in posterior regions of the gastrula, while its function in more anterior regions is largely redundant to that of Slb/Wnt11. Frizzled-2 functions downstream of ppt/wnt5, indicating that it might act as a receptor for Ppt/Wnt5 in this process. The characterisation of the role of Ppt/Wnt5 provides insight into the functional diversity of Wnt genes in regulating vertebrate gastrulation movements. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：467 / 476

页数：10

共 37 条

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