Tocopherol long chain fatty alcohols decrease the production of TNF-α and NO radicals by activated microglial cells

被引：13

作者：

Muller, T

Grandbarbe, L

Morga, E

Heuschling, P

Luu, B ^{[1
]}

机构：

[1] Univ Strasbourg 1, CNRS, UMR 7123, Lab Chim Organ Subst Nat, F-67084 Strasbourg, France

[2] Univ Luxembourg, Fac Sci Technol & Commun, Lab Neurobiol, L-1511 Luxembourg, Luxembourg

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 24期

关键词：

tocopherol; long chain fatty alkanol; neuroinflammation; microglia;

D O I：

10.1016/j.bmcl.2004.09.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of Tocopherol long chain Fatty Alcohols (TEA) and their biological activities on the modulation of microglial activation are described. Specifically, the 2-(12-hydroxy-dodecyl)-2,5,7,8-tetramethyl-chroman-6-ol, the TEA bearing 12 carbon atoms on the side chain (n = 12), shows the most potent inhibition of secretion on nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) by lipopolysaccharide (LPS)-activated microglia. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：6023 / 6026

页数：4

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