Chemical modifications of bile acids under high-intensity ultrasound or microwave irradiation

被引：15

作者：

Cravotto, G

Boffa, L

Turello, M

Parenti, M

Barge, A

机构：

[1] Univ Turin, Dipartimento Sci & Tecnol Farm, I-10125 Turin, Italy

[2] Prodotti Chim & Alimentali Spa, I-15060 Basaluzzo, AL, Italy

[3] Univ Turin, Dipartimento Chim, IFM, I-10125 Turin, Italy

来源：

STEROIDS | 2005年 / 70卷 / 02期

关键词：

high-intensity ultrasound; microwave; synthesis; cholic acid; glycocholic acid; taurocholic acid;

D O I：

10.1016/j.steroids.2004.09.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

High-intensity ultrasound (HIU) and microwave (MW) irradiation, having emerged as effective promoters of organic reactions, were exploited for the synthesis of bile acids derivatives. Esterification, amidation, hydrolysis, oxidation, and reduction were investigated. Compared to conventional methods, both techniques proved much more efficient, increasing product yields and dramatically cutting down reaction times. Scaled-up studies are now under way. (C) 2004 Elsevier Inc. All rights reserved.

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页码：77 / 83

页数：7

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