Angiogenesis assays: Problems and pitfalls

被引:114
作者
Auerbach, R [1 ]
Akhtar, N [1 ]
Lewis, RL [1 ]
Shinners, BL [1 ]
机构
[1] Univ Wisconsin, Dev Biol Lab, Madison, WI 53705 USA
关键词
angiogenesis; methodology; animal models; assay;
D O I
10.1023/A:1026574416001
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Many studies of angiogenesis inducers and inhibitors rely on in vitro or in vivo models as indicators of efficacy. However, as valuable as these models are, there are limitations to each one of these. This overview describes some of the principal methods now in use and discusses the advantages and some of the limitations of these methods. It is suggested that multiple assays, involving both in vitro and in vivo assays, are at present the best way to minimize the problems inherent in any specific assay.
引用
收藏
页码:167 / 172
页数:6
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