Stereochemistry of the reduction of 24-ethyldesmosterol to sitosterol in tissue cultures of Oryza sativa

被引：11

作者：

Fujimoto, Y ^{[1
]}

Sato, N

Okuzumi, T

Yamada, J

Morisaki, M

机构：

[1] Tokyo Inst Technol, Dept Chem, Meguro Ku, Tokyo 152, Japan

[2] Kyoritsu Coll Pharm, Minato Ku, Tokyo 105, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(97)10220-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Feeding of [26-C-13]- and [27-C-13]-24-ethyldesmosterols to cultured cells of Oryza sativa followed by C-13-NMR analysis of the biosynthesized sitosterol revealed that the reduction of 24(25)-double bond proceeds with an anti-addition of hydrogen atoms, thus the E-methyl group of the olefinic precursor becomes the pro-S-methyl on C-25 of sitosterol. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：205 / 208

页数：4

共 15 条

[1]

STEROLS OF KALANCHOE-PINNATA - 1ST REPORT OF THE ISOLATION OF BOTH C-24 EPIMERS OF 24-ALKYL-DELTA-25-STEROLS FROM A HIGHER-PLANT [J].