Associations with autoimmune disorders and HLA class I and II antigens in inclusion body myositis

被引：69

作者：

Badrising, UA

Schreuder, GMT

Giphart, MJ

Geleijns, K

Verschuuren, JJGM

Wintzen, AR

机构：

[1] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2300 RC Leiden, Netherlands

来源：

NEUROLOGY | 2004年 / 63卷 / 12期

关键词：

D O I：

10.1212/01.WNL.0000148588.15052.4C

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Whether autoimmune mechanisms play a role in the pathogenesis of inclusion body myositis (IBM) is unknown. Human leukocyte antigen (HLA) analysis in 52 patients, including 17 with autoimmune disorders (AIDs), showed that patients were more likely to have antigens from the autoimmune-prone HLA-B8-DR3 ancestral haplotype than healthy control subjects, irrespective of the presence of AIDs. Patients lacked the apparently protective HLA-DR53 antigen. The results provide further support for an autoimmune basis in IBM.

引用

页码：2396 / 2398

页数：3

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