Galectin-3 in Renal Pathology: More Than Just an Innocent Bystander?

被引：61

作者：

Desmedt, Valerie ^{[1
]}

Desmedt, Stephanie ^{[1
]}

Delanghe, Joris R. ^{[2
]}

Speeckaert, Reinhart ^{[2
]}

Speeckaert, Marijn M. ^{[1
]}

机构：

[1] Ghent Univ Hosp, Dept Nephrol, De Pintelaan 185, BE-9000 Ghent, Belgium

[2] Ghent Univ Hosp, Dept Clin Chem, BE-9000 Ghent, Belgium

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 2016年 / 43卷 / 05期

关键词：

Galectin-3; Kidney disease; Lectin; Renal fibrosis; CARBOHYDRATE-RECOGNITION DOMAIN; FAMILIAL MEDITERRANEAN FEVER; POLYCYSTIC KIDNEY-DISEASE; HEART-FAILURE PATIENTS; EPITHELIAL-CELLS; KNOCKOUT MICE; HYPERTENSIVE NEPHROPATHY; INTERSTITIAL FIBROSIS; DIABETIC-NEPHROPATHY; SERUM GALECTIN-3;

D O I：

10.1159/000446376

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Galectin-3 is a member of a closely related lectin family, which is detected in several vertebrate epithelial and myeloid cell types. This beta-galactoside-binding soluble protein plays an important role in multiple biological processes. Depending on its location, type of injury or site of damage, the effects by galectin-3 can be various and sometimes contrasting. Summary: In this review, we discuss the general characteristics and functions of galectin-3. More specifically, we focus on the role of galectin-3 in the onset and development of diabetic and non-diabetic nephropathies. Finally, the therapeutic potential of anti-galectin-3 inhibitors is discussed. Key Messages: Due to its multifunctional character, galectin-3 plays a pivotal role in interstitial fibrosis and progression of chronic kidney disease. Inhibition of galectin-3 may be a promising therapeutic strategy to prevent end-stage renal disease. (C) 2016 S. Karger AG, Basel

引用

页码：305 / 317

页数：13

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