Effect of benidipine hydrochloride, a dihydropyridine-type calcium antagonist, on the function of mouse osteoblastic cells

被引：22

作者：

Kosaka, N ^{[1
]}

Uchii, M ^{[1
]}

机构：

[1] Kyowa Hakko Kogyo Co Ltd, Pharmaceut Res Inst, Drug Discovery Labs, Nagaizumi, Shizuoka 411, Japan

来源：

CALCIFIED TISSUE INTERNATIONAL | 1998年 / 62卷 / 06期

关键词：

benidipine hydrochloride; calcium antagonist; osteoblast;

D O I：

10.1007/s002239900478

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The effects of benidipine hydrochloride (BD), a dihydropyridine-type calcium antagonist, on the growth and alkaline phosphatase (ALPase) activity were studied in cultures of mouse osteoblastic cells. ED (0.1-10 nM) increased the ALPase activity of osteoblastic cells and reduced cell proliferation incubated for 48 h. This reduction of cell growth did not appear to be due to cell death. On the other hand, nifedipine and amlodipine (1 nM) had no effect. ED (0.1-10 nM) enhanced the effects of 1,25(OH)(2)D-3 on osteoblastic cells, the decreased cell growth and increased ALPase activity. These findings suggest that ED regulates the growth and differentiation of osteoblasts and stimulates the function of these cells as well as 1,25(OH)(2)D-3.

引用

页码：554 / 556

页数：3

共 6 条

[1]

DEXAMETHASONE AND 1,25-DIHYDROXYVITAMIN-D3 MODULATION OF INSULIN-LIKE GROWTH FACTOR-BINDING PROTEINS IN RAT OSTEOBLAST-LIKE CELL-CULTURES [J].